Mouse Anti-PAIP2 Recombinant Antibody (1C12) (CBMAB-P0687-YC)

Provided herein is a Mouse monoclonal antibody against Human Poly(A) Binding Protein Interacting Protein 2. The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all PAIP2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1C12

Antibody Isotype

IgG2b

Application

WB, ELISA

Basic Information

Immunogen

Recombinant human PAIP2 (1-127aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Poly(A) Binding Protein Interacting Protein 2

Introduction

PAIP2 has ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues.

Entrez Gene ID

51247

UniProt ID

Q9BPZ3

Alternative Names

Poly(A) Binding Protein Interacting Protein 2; PABP-Interacting Protein 2; PAIP-2; PAIP2A; Polyadenylate-Binding Protein-Interacting Protein 2; Poly(A)-Binding Protein-Interacting Protein 2; PolyA-Binding Protein-Interacting Protein 2; PABC1-Interacting Protein 2;

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Biological Process

MemoryIEA:Ensembl
Negative regulation of translationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of long-term synaptic potentiationIEA:Ensembl
SpermatogenesisIEA:Ensembl

Cellular Location

Cytoplasm

PTM

Ubiquitinated, leading to its degradation by the proteasome.

References

Wang, C., Jiang, X., & Qi, J. (2022). PAIP2 is a potential diagnostic and prognostic biomarker of breast cancer and is associated with immune infiltration. Frontiers in Genetics, 13, 1009056.

Xie, J., Wei, X., Kozlov, G., Chen, Y., Menade, M., & Gehring, K. (2021). Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation. bioRxiv, 2021-02.v

Kachaev, Z. M., Lebedeva, L. A., Shaposhnikov, A. V., Moresco, J. J., Yates III, J. R., Schedl, P., & Shidlovskii, Y. V. (2019). Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila. FEBS letters, 593(10), 1102-1112.

Ivanov, A., Shuvalova, E., Egorova, T., Shuvalov, A., Sokolova, E., Bizyaev, N., ... & Alkalaeva, E. (2019). Polyadenylate-binding protein–interacting proteins PAIP1 and PAIP2 affect translation termination. Journal of Biological Chemistry, 294(21), 8630-8639.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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