PAK1IP1

PAK1IP1 has ubiquitous expression in prostate (RPKM 23.6), appendix (RPKM 6.7) and 24 other tissues.

PAK1 Interacting Protein 1

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).

Cell population proliferationIEA:Ensembl
Negative regulation of signal transductionIEA:UniProtKB-KW
Regulation of signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Roof of mouth developmentIEA:Ensembl

Nucleus, nucleolus