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PAK1IP1

PAK1IP1 has ubiquitous expression in prostate (RPKM 23.6), appendix (RPKM 6.7) and 24 other tissues.

Full Name

PAK1 Interacting Protein 1

Function

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).

Biological Process

Cell population proliferationIEA:Ensembl
Negative regulation of signal transductionIEA:UniProtKB-KW
Regulation of signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Roof of mouth developmentIEA:Ensembl

Cellular Location

Nucleus, nucleolus

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Anti-PAK1IP1 antibodies

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Mouse Anti-PAK1IP1 Recombinant Antibody (CBYC-P144) (CBMAB-P0693-YC)

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Target: PAK1IP1

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Rat

Clone: CBYC-P144

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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