PBXIP1

PBXIP1 interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer.

Full Name

pre-B-cell leukemia homeobox interacting protein 1

Function

Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

Biological Process

Articular cartilage developmentIEA:Ensembl
Cell adhesionIEA:Ensembl
Cell differentiationIEA:InterPro
Cell migrationIEA:Ensembl
Extracellular matrix disassemblyIEA:Ensembl
Gene expression involved in extracellular matrix organizationIEA:Ensembl
HemopoiesisManual Assertion Based On ExperimentIEP:UniProtKB
Histone H3-K56 acetylationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of chondrocyte proliferationIEA:Ensembl
Positive regulation of Wnt signaling pathwayIEA:Ensembl
Production of molecular mediator involved in inflammatory responseIEA:Ensembl
Regulation of Rho guanyl-nucleotide exchange factor activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Nucleus
Shuttles between the nucleus and the cytosol (PubMed:12360403).
Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403).
Detected in small amounts in the nucleus (PubMed:10825160).