Mouse Anti-PBXIP1 Recombinant Antibody (CBYC-P194) (CBMAB-P0941-YC)

Name: Mouse Anti-PBXIP1 Recombinant Antibody (CBYC-P194)
SKU: CBMAB-P0941-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-P194

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

pre-B-cell leukemia homeobox interacting protein 1

Introduction

PBXIP1 interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer.

Entrez Gene ID

57326

UniProt ID

Q96AQ6

Alternative Names

HPIP

Function

Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

Biological Process

Articular cartilage developmentIEA:Ensembl
Cell adhesionIEA:Ensembl
Cell differentiationIEA:InterPro
Cell migrationIEA:Ensembl
Extracellular matrix disassemblyIEA:Ensembl
Gene expression involved in extracellular matrix organizationIEA:Ensembl
HemopoiesisManual Assertion Based On ExperimentIEP:UniProtKB
Histone H3-K56 acetylationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of chondrocyte proliferationIEA:Ensembl
Positive regulation of Wnt signaling pathwayIEA:Ensembl
Production of molecular mediator involved in inflammatory responseIEA:Ensembl
Regulation of Rho guanyl-nucleotide exchange factor activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Nucleus
Shuttles between the nucleus and the cytosol (PubMed:12360403).
Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403).
Detected in small amounts in the nucleus (PubMed:10825160).

Zhang, J., Sun, X., Jia, X., Sun, B., Xu, S., Zhang, W., & Liu, Z. (2024). Integrative multi‐omics analysis reveals the critical role of the PBXIP1 gene in Alzheimer's disease. Aging Cell, 23(2), e14044.

Krasnytska, D. O., Viletska, Y. M., Minchenko, D. O., Khita, O. O., Tsymbal, D. O., Cherednychenko, A. A., ... & Minchenko, O. H. (2023). ERN1 dependent impact of glucose and glutamine deprivations on PBX3, PBXIP1, PAX6, MEIS1, and MEIS2 genes expression in U87 glioma cells. Endocrine Regulations, 57(1), 37-47.

Ilmer, M., Renz, B. W., Kühn, F., Drefs, M., Koliogiannis, D., Werner, J., ... & Woischke, C. (2022). PBXIP1–An indicator for poor outcome and metastatic spread in colorectal cancer. Pathology-Research and Practice, 236, 153993.

Liu, Z., Zhang, J., & Sun, X. (2022). INTEGRATIVE MULTI-OMICS ANALYSIS REVEALS THE CRITICAL ROLE OF PBXIP1 GENE IN AGING-RELATED ALZHEIMER'S DISEASE. Innovation in Aging, 6(Suppl 1), 589.

Khumukcham, S. S., & Manavathi, B. (2021). Two decades of a protooncogene HPIP/PBXIP1: uncovering the tale from germ cell to cancer. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188576.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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