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Mouse Anti-PBXIP1 Recombinant Antibody (CBYC-P194) (CBMAB-P0941-YC)

Provided herein is a Mouse monoclonal antibody against Human PBX Homeobox Interacting Protein 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PBXIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P194
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pre-B-cell leukemia homeobox interacting protein 1
Introduction
PBXIP1 interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer.
Entrez Gene ID
57326
UniProt ID
Q96AQ6
Alternative Names
HPIP
Function
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
Biological Process
Articular cartilage developmentIEA:Ensembl
Cell adhesionIEA:Ensembl
Cell differentiationIEA:InterPro
Cell migrationIEA:Ensembl
Extracellular matrix disassemblyIEA:Ensembl
Gene expression involved in extracellular matrix organizationIEA:Ensembl
HemopoiesisManual Assertion Based On ExperimentIEP:UniProtKB
Histone H3-K56 acetylationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of chondrocyte proliferationIEA:Ensembl
Positive regulation of Wnt signaling pathwayIEA:Ensembl
Production of molecular mediator involved in inflammatory responseIEA:Ensembl
Regulation of Rho guanyl-nucleotide exchange factor activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Nucleus
Shuttles between the nucleus and the cytosol (PubMed:12360403).
Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403).
Detected in small amounts in the nucleus (PubMed:10825160).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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