PCBP1

PCBP1 is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Full Name
Poly(RC) Binding Protein 1
Function
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).
Biological Process
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of RNA metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Viral RNA genome replicationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
PTM
Phosphorylated; lowers poly(rC)-binding activity.
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Anti-PCBP1 antibodies

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Mouse Anti-PCBP1 Recombinant Antibody (3B9) (CBMAB-P0949-YC)

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Target: PCBP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B9
Application*: WB, IH
Datasheet SDS

Mouse Anti-PCBP1 Recombinant Antibody (2A10) (CBMAB-P0948-YC)

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Target: PCBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A10
Application*: WB, E
Datasheet SDS

Mouse Anti-PCBP1 Recombinant Antibody (1G2) (CBMAB-P0947-YC)

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Target: PCBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G2
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-PCBP1 (AA 1-225) Recombinant Antibody (CBFYH-2700) (CBMAB-H3758-FY)

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Target: PCBP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2700
Application*: P, WB
Datasheet SDS

Mouse Anti-PCBP1 (AA 1-225) Recombinant Antibody (CBFYH-2699) (CBMAB-H3757-FY)

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Target: PCBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2699
Application*: WB
Datasheet SDS

Mouse Anti-PCBP1 Recombinant Antibody (CBFYH-2698) (CBMAB-H3756-FY)

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Target: PCBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-2698
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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