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Mouse Anti-PCBP1 (AA 1-225) Recombinant Antibody (CBFYH-2700) (CBMAB-H3758-FY)

This product is mouse antibody that recognizes PCBP1. The antibody CBFYH-2700 can be used for immunoassay techniques such as: IHC-P, WB.
See all PCBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2700
Antibody Isotype
IgG2b
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-225

Target

Full Name
Poly(RC) Binding Protein 1
Introduction
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Entrez Gene ID
5093
UniProt ID
Q15365
Alternative Names
Poly(RC) Binding Protein 1; Heterogeneous Nuclear Ribonucleoprotein E1; Nucleic Acid-Binding Protein SUB2.3; Poly(RC)-Binding Protein 1; Alpha-CP1; Heterogenous Nuclear Ribonucleoprotein E1; Heterogenous Nuclear Ribonucleoprotein X; Epididymis Secretory Protein Li 85
Function
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).
Biological Process
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of RNA metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Viral RNA genome replicationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
PTM
Phosphorylated; lowers poly(rC)-binding activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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