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PDCD1LG2

PDCD1LG2 (Programmed Cell Death 1 Ligand 2) is a Protein Coding gene. Diseases associated with PDCD1LG2 include Cysticercosis and Myasthenic Syndrome, Congenital, 14. Among its related pathways are Innate Immune System and NF-kappaB Signaling. An important paralog of this gene is CD274.

Full Name

Programmed Cell Death 1 Ligand 2

Function

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
T cell costimulationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform 3
Secreted
Isoform 2
Endomembrane system
Isoform 1
Cell membrane

Topology

Extracellular: 20-220
Helical: 221-241
Cytoplasmic: 242-273

Anti-PDCD1LG2 antibodies

Rabbit Anti-PDCD1LG2 Recombinant Antibody (CBYY-1146) (CBMAB-1150-YY)

SDS

Target: PDCD1LG2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBYY-1146

Application*: WB

Rabbit Anti-PDCD1LG2 Recombinant Antibody (CBYY-1145) (CBMAB-1149-YY)

SDS

Target: PDCD1LG2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-1145

Application*: F

Mouse Anti-PDCD1LG2 Recombinant Antibody (CBWJC-2358) (CBMAB-C3305WJ)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJC-2358

Application*: F, E, B

Rat Anti-PDCD1LG2 Recombinant Antibody (CBXC-1462) (CBMAB-C3503-CQ)

SDS

Target: PDCD1LG2

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXC-1462

Application*: F, IP, WB

Rat Anti-PDCD1LG2 Recombinant Antibody (CBXC-1386) (CBMAB-C2613-CQ)

SDS

Target: PDCD1LG2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXC-1386

Application*: F, IH, IP

Mouse Anti-PDCD1LG2 Recombinant Antibody (MIH18) (CBMAB-C1796-CQ)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MIH18

Application*: F

Mouse Anti-PDCD1LG2 Recombinant Antibody (CBFYC-3024) (CBMAB-C3101-FY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3024

Application*: F

Mouse Anti-PDCD1LG2 Recombinant Antibody (CBFYC-3023) (CBMAB-C3100-FY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3023

Application*: F, IH

Mouse Anti-PDCD1LG2 Recombinant Antibody (CBFYC-3022) (CBMAB-C3099-FY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-3022

Application*: F, IH, WB

Rat Anti-PDCD1LG2 Recombinant Antibody (CBFYC-0241) (CBMAB-C0270-FY)

SDS

Target: PDCD1LG2

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBFYC-0241

Application*: F

Rat Anti-PDCD1LG2 Recombinant Antibody (54-1) (CBMAB-C7166-LY)

SDS

Target: PDCD1LG2

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 54-1

Application*: F

Mouse Anti-PDCD1LG2 Recombinant Antibody (176611) (CBMAB-C3428-LY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 176611

Application*: F, C, WB

Mouse Anti-PDCD1LG2 Recombinant Antibody (24F.10C12) (CBMAB-C0733-LY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 24F.10C12

Application*: F

Mouse Anti-PDCD1LG2 Recombinant Antibody (10B1186) (CBMAB-C0138-LY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B1186

Application*: F, IH

Rat Anti-PDCD1LG2 Recombinant Antibody (A1403) (CBMAB-AP11410LY)

SDS

Target: PDCD1LG2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: A1403

Application*: FC, IHC, IP, WB

Mouse Anti-PDCD1LG2 Recombinant Antibody (3E9) (CBMAB-A6497-LY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3E9

Application*: WB, E

Mouse Anti-PDCD1LG2 Recombinant Antibody (6E4) (CBMAB-A6495-LY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6E4

Application*: E, E

Mouse Anti-PDCD1LG2 Recombinant Antibody (2E2) (CBMAB-A6494-LY)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E2

Application*: WB, E

Recombinant Mouse Anti-PDCD1LG2 Recombinant Antibody (Z64P2D3) (CBMAB-XB0915-YC)

SDS

Target: PDCD1LG2

Host: Mouse

Specificity: Human

Clone: Z64P2D3

Application*: E, IH, WB

Mouse Anti-PDCD1LG2 Recombinant Antibody (Z64P2D3/H4) (CBMAB-P1154-YC)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: Z64P2D3/H4

Application*: WB, E, IH

Rat Anti-PDCD1LG2 Recombinant Antibody (TY25) (CBMAB-P1153-YC)

SDS

Target: PDCD1LG2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: TY25

Application*: F, IH, C

Rat Anti-PDCD1LG2 Recombinant Antibody (MIH5) (CBMAB-P1152-YC)

SDS

Target: PDCD1LG2

Host: Rat

Antibody Isotype: IgG2a, λ

Specificity: Mouse

Clone: MIH5

Application*: F

Mouse Anti-PDCD1LG2 Recombinant Antibody (MIH14) (CBMAB-P1151-YC)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MIH14

Application*: F, C

Mouse Anti-PDCD1LG2 Recombinant Antibody (ANC8D12) (CBMAB-P1150-YC)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: ANC8D12

Application*: B, E, F

Mouse Anti-PDCD1LG2 Recombinant Antibody (7C1) (CBMAB-P1148-YC)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 7C1

Application*: E, WB, P, IC, IF, F

Mouse Anti-PDCD1LG2 Recombinant Antibody (4E10) (CBMAB-P1147-YC)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4E10

Application*: E, WB, P, IC, IF, F

Mouse Anti-PDCD1LG2 Recombinant Antibody (10B6) (CBMAB-P1144-YC)

SDS

Target: PDCD1LG2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 10B6

Application*: WB, F, IH, P

PDCD1LG2 Matched Antibody Pair (852) (APMAB-852LY)

SDS

Target: PDCD1LG2

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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