PDCD1LG2
PDCD1LG2 (Programmed Cell Death 1 Ligand 2) is a Protein Coding gene. Diseases associated with PDCD1LG2 include Cysticercosis and Myasthenic Syndrome, Congenital, 14. Among its related pathways are Innate Immune System and NF-kappaB Signaling. An important paralog of this gene is CD274.
Full Name
Programmed Cell Death 1 Ligand 2
Alternative Names
Programmed Cell Death 1 Ligand 2; B7 Dendritic Cell Molecule; Programmed Death Ligand 2; Butyrophilin B7-DC; PDCD1 Ligand 2; PDCD1L2; B7-DC; CD273; PD-L2;
Function
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
T cell costimulationManual Assertion Based On ExperimentIBA:GO_Central
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
T cell costimulationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 3
Secreted
Isoform 2
Endomembrane system
Isoform 1
Cell membrane
Secreted
Isoform 2
Endomembrane system
Isoform 1
Cell membrane
Topology
Extracellular: 20-220
Helical: 221-241
Cytoplasmic: 242-273
Helical: 221-241
Cytoplasmic: 242-273
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Anti-PDCD1LG2 antibodies
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Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIH14
Application*: F, C
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: AG148
Application*: B, F
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG147
Application*: F, C, IP, WB
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A1403
Application*: FC, IHC, IP, WB
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E9
Application*: WB, E
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6E4
Application*: E, E
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E2
Application*: WB, E
Target: PDCD1LG2
Host: Mouse
Specificity: Human
Clone: Z64P2D3
Application*: E, IH, WB
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Z64P2D3/H4
Application*: WB, E, IH
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: TY25
Application*: F, IH, C
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG2a, λ
Specificity: Mouse
Clone: MIH5
Application*: F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: ANC8D12
Application*: B, E, F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7C1
Application*: E, WB, P, IC, IF, F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E10
Application*: E, WB, P, IC, IF, F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 10B6
Application*: WB, F, IH, P
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 54-1
Application*: F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 176611
Application*: F, C, WB
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 24F.10C12
Application*: F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B1186
Application*: F, IH
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: His Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: hFc Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: His Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: His Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: hFc Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: His Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: hFc Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: hFc & AVI Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: Fc Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: His Tag
Compare
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: His & AVI Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: His Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-219
Tag: hFc Tag
Target: PDCD1LG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 74-274
Tag: His Tag
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4273
Application*: F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4161
Application*: WB, IC, F
Target: PDCD1LG2
Specificity: Human
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-2358
Application*: F, E, B
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1462
Application*: F, IP, WB
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1386
Application*: F, IH, IP
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIH18
Application*: F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3024
Application*: F
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3023
Application*: F, IH
Target: PDCD1LG2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-3022
Application*: F, IH, WB
Target: PDCD1LG2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYC-0241
Application*: F
Target: PDCD1LG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYY-1146
Application*: WB
Target: PDCD1LG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1145
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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