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Rat Anti-PDCD1LG2 Recombinant Antibody (CBXC-1462) (CBMAB-C3503-CQ)

This product is a rat antibody that recognizes PDCD1LG2. The antibody CBXC-1462 can be used for immunoassay techniques such as: FC, IP, WB.
See all PDCD1LG2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1462
Antibody Isotype
IgG2
Application
FC, IP, WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse B7-DC
Specificity
Mouse
Antibody Isotype
IgG2
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized powder from PBS. Reconstitute with PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Programmed Cell Death 1 Ligand 2
Introduction
Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
Entrez Gene ID
58205
UniProt ID
Q9WUL5
Alternative Names
Programmed Cell Death 1 Ligand 2; B7 Dendritic Cell Molecule; Programmed Death Ligand 2; Butyrophilin B7-DC; PDCD1 Ligand 2; PDCD1L2; B7-DC; CD273; PD-L2;
Function
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
T cell costimulationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 3
Secreted
Isoform 2
Endomembrane system
Isoform 1
Cell membrane
Topology
Extracellular: 20-220
Helical: 221-241
Cytoplasmic: 242-273
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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