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Rat Anti-PDCD1LG2 Recombinant Antibody (TY25) (CBMAB-P1153-YC)

Provided herein is a Rat monoclonal antibody against Mouse Programmed Cell Death 1 Ligand 2. The antibody can be used for immunoassay techniques, such as FC, IHC, IHC-Fr.
See all PDCD1LG2 antibodies
Published Data
Fig.1 IRF4 regulates tolerogenic maturation but not immunogenic signals.
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Fig.2 Inflamed islets from 10-wk-old unmanipulated prediabetic female NOD mice showing negative staining with negative PD-L2 staining.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
TY25
Antibody Isotype
IgG2a
Application
FC, IHC, IHC-Fr

Basic Information

Immunogen
B7-DC transfected RAW264.7 cells
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Programmed Cell Death 1 Ligand 2
Introduction
PDCD1LG2 has broad expression in spleen (RPKM 7.3), lymph node (RPKM 5.3) and 21 other tissues.
Entrez Gene ID
58205
UniProt ID
Q9WUL5
Alternative Names
Programmed Cell Death 1 Ligand 2; B7 Dendritic Cell Molecule; Programmed Death Ligand 2; Butyrophilin B7-DC; PDCD1 Ligand 2; PDCD1L2; B7-DC; CD273; PD-L2;
Function
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of activated T cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
T cell costimulationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 3
Secreted
Isoform 2
Endomembrane system
Isoform 1
Cell membrane
Topology
Extracellular: 20-220
Helical: 221-241
Cytoplasmic: 242-273
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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