PDE3B

PDE3B has biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues.

Full Name

phosphodiesterase 3B, cGMP-inhibited

Function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Biological Process

AngiogenesisIEA:UniProtKB-KW
Cellular response to insulin stimulusISS:BHF-UCL
G protein-coupled receptor signaling pathwayTAS:Reactome
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell adhesionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell adhesion mediated by integrin1 PublicationIC:BHF-UCL
Negative regulation of lipid catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane