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PDE3B

PDE3B has biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues.

Full Name

phosphodiesterase 3B, cGMP-inhibited

Function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Biological Process

AngiogenesisIEA:UniProtKB-KW
Cellular response to insulin stimulusISS:BHF-UCL
G protein-coupled receptor signaling pathwayTAS:Reactome
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell adhesionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell adhesion mediated by integrin1 PublicationIC:BHF-UCL
Negative regulation of lipid catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

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Anti-PDE3B antibodies

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Rat Anti-PDE3B Recombinant Antibody (SMCP3B) (CBMAB-P1206-YC)

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Target: PDE3B

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: SMCP3B

Application*: F, WB

Mouse Anti-PDE3B Recombinant Antibody (4A4) (CBMAB-P1205-YC)

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Target: PDE3B

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4A4

Application*: E, WB

Human Recombinant PDE3B, Active protein, GST Tag (V2LY-0526-LY6032)

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Target: PDE3B

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 654-end

Tag: GST Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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