Mouse Anti-PDE3B Recombinant Antibody (4A4) (CBMAB-P1205-YC)

Name: Mouse Anti-PDE3B Recombinant Antibody (4A4)
SKU: CBMAB-P1205-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4A4

Application

ELISA, WB

Immunogen

PDE3B (NP_000913, 401-501 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phosphodiesterase 3B, cGMP-inhibited

Introduction

PDE3B has biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues.

Entrez Gene ID

5140

UniProt ID

Q13370

Alternative Names

Phosphodiesterase 3B; Cyclic GMP-Inhibited Phosphodiesterase B; Phosphodiesterase 3B, CGMP-Inhibited; EC 3.1.4.17; CGI-PDE B; CGIPDE1;

Function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Biological Process

AngiogenesisIEA:UniProtKB-KW
Cellular response to insulin stimulusISS:BHF-UCL
G protein-coupled receptor signaling pathwayTAS:Reactome
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell adhesionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell adhesion mediated by integrin1 PublicationIC:BHF-UCL
Negative regulation of lipid catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rat Anti-PDE3B Recombinant Antibody (SMCP3B) (CAT#: CBMAB-P1206-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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