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Mouse Anti-PDE3B Recombinant Antibody (4A4) (CBMAB-P1205-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 3B. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PDE3B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PDE3B (NP_000913, 401-501 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphodiesterase 3B, cGMP-inhibited
Introduction
PDE3B has biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues.
Entrez Gene ID
5140
UniProt ID
Q13370
Alternative Names
Phosphodiesterase 3B; Cyclic GMP-Inhibited Phosphodiesterase B; Phosphodiesterase 3B, CGMP-Inhibited; EC 3.1.4.17; CGI-PDE B; CGIPDE1;
Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Biological Process
AngiogenesisIEA:UniProtKB-KW
Cellular response to insulin stimulusISS:BHF-UCL
G protein-coupled receptor signaling pathwayTAS:Reactome
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell adhesionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell adhesion mediated by integrin1 PublicationIC:BHF-UCL
Negative regulation of lipid catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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