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Rat Anti-PDE3B Recombinant Antibody (SMCP3B) (CBMAB-P1206-YC)

Provided herein is a Rat monoclonal antibody against Mouse Phosphodiesterase 3B. The antibody can be used for immunoassay techniques, such as FC, WB.
See all PDE3B antibodies
Published Data
Fig. 1 PDE3B expression in WT and TregΔ142 Tregs by Western blot.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
SMCP3B
Antibody Isotype
IgG2a, κ
Application
FC, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphodiesterase 3B, cGMP-inhibited
Introduction
PDE3B has biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues.
Entrez Gene ID
18576
UniProt ID
Q61409
Alternative Names
Phosphodiesterase 3B; Cyclic GMP-Inhibited Phosphodiesterase B; Phosphodiesterase 3B, CGMP-Inhibited; EC 3.1.4.17; CGI-PDE B; CGIPDE1;
Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Biological Process
AngiogenesisIEA:UniProtKB-KW
Cellular response to insulin stimulusISS:BHF-UCL
G protein-coupled receptor signaling pathwayTAS:Reactome
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell adhesionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell adhesion mediated by integrin1 PublicationIC:BHF-UCL
Negative regulation of lipid catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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