PDE6G

PDE6G is the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha-and beta-catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2.

Full Name

Phosphodiesterase 6G

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Biological Process

Positive regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of MAPK cascadeIEA:Ensembl
Response to stimulusIEA:UniProtKB-KW
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

photoreceptor disc membrane
photoreceptor outer segment membrane
plasma membrane

Involvement in disease

Retinitis pigmentosa 57 (RP57):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.