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Mouse Anti-PDE6G Recombinant Antibody (1E11) (CBMAB-P1226-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 6G. The antibody can be used for immunoassay techniques, such as FC, WB.
See all PDE6G antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E11
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Immunogen
A full length recombinant protein of human PDE6G (NP_002593) produced in HEK293T cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphodiesterase 6G
Introduction
PDE6G is the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha-and beta-catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2.
Entrez Gene ID
5148
UniProt ID
P18545
Alternative Names
Phosphodiesterase 6G; Phosphodiesterase 6G, CGMP-Specific, Rod, Gamma; GMP-PDE Gamma; PDEG; Retinal Rod Rhodopsin-Sensitive CGMP 3,5-Cyclic Phosphodiesterase Subunit Gamma; Rod CG-PDE G; EC 3.1.4.17; EC 3.1.4.35; RP57;
Function
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Biological Process
Positive regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of MAPK cascadeIEA:Ensembl
Response to stimulusIEA:UniProtKB-KW
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
photoreceptor disc membrane
photoreceptor outer segment membrane
plasma membrane
Involvement in disease
Retinitis pigmentosa 57 (RP57):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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