PDK1

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
Full Name
Pyruvate Dehydrogenase Kinase 1
Function
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Glucose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Hypoxia-inducible factor-1alpha signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Intrinsic apoptotic signaling pathway in response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of acetyl-CoA biosynthetic process from pyruvateTAS:Reactome
Regulation of glucose metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion matrix
PTM
Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-243 and Tyr-244 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect.
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Anti-PDK1 antibodies

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Rabbit Anti-PDK1 Recombinant Antibody (D37A7) (CBMAB-CP1922-LY)

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Target: PDK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D37A7
Application*: WB
Datasheet SDS

Rabbit Anti-PDK1 Recombinant Antibody (D4Q4D) (CBMAB-CP1921-LY)

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Target: PDK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D4Q4D
Application*: WB
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (3E1) (CBMAB-A6538-LY)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E1
Application*: SE, E
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (CBYC-P268) (CBMAB-P1315-YC)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYC-P268
Application*: E
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (4A11) (CBMAB-P1314-YC)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: 4A11
Application*: E, F, IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (2D6) (CBMAB-P1312-YC)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D6
Application*: WB, F, E, IC, IF
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (13B613) (CBMAB-P1311-YC)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: 13B613
Application*: E, F, IH, WB
Datasheet SDS

Rabbit Anti-PDK1 Recombinant Antibody (10E44) (CBMAB-P1310-YC)

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Target: PDK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 10E44
Application*: IP, WB
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (CBFYM-3052) (CBMAB-M3248-FY)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human
Clone: CBFYM-3052
Application*: WB, F, IF, E
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (CBT1013) (V2LY-0625-LY3109)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Monkey
Clone: CBT1013
Application*: WB, P, IF, IC, F, E
Datasheet SDS

Mouse Anti-PDK1 Recombinant Antibody (CBT4278) (V2LY-0625-LY2576)

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Target: PDK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: CBT4278
Application*: WB, IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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