PELI1

PELI1 has broad expression in bone marrow (RPKM 57.0), esophagus (RPKM 14.7) and 19 other tissues.

Full Name

Pellino E3 Ubiquitin Protein Ligase 1

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297).
Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609).
Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609).
Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).

Biological Process

Negative regulation of necroptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of NF-kappaB transcription factor activityIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Positive regulation of B cell proliferationIEA:Ensembl
Positive regulation of cytokine productionIEA:Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signalingTAS:Reactome
Positive regulation of protein ubiquitinationIEA:Ensembl
Positive regulation of toll-like receptor 3 signaling pathwayIEA:Ensembl
Positive regulation of toll-like receptor 4 signaling pathwayIEA:Ensembl
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Protein K48-linked ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Protein K63-linked ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of necroptotic processTAS:Reactome
Regulation of Toll signaling pathwayIEA:InterPro
Response to dsRNAIEA:Ensembl
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:ARUK-UCL

Cellular Location

cytosol
nucleus

PTM

Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity.
Sumoylated.