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Mouse Anti-PELI1 Recombinant Antibody (1D9) (CBMAB-P1432-YC)

Provided herein is a Mouse monoclonal antibody against Human Pellino E3 Ubiquitin Protein Ligase 1. The antibody can be used for immunoassay techniques, such as IHC, WB.
See all PELI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D9
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-245 of human PELI1(NP_065702) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pellino E3 Ubiquitin Protein Ligase 1
Introduction
PELI1 has broad expression in bone marrow (RPKM 57.0), esophagus (RPKM 14.7) and 19 other tissues.
Entrez Gene ID
57162
UniProt ID
Q96FA3
Alternative Names
Pellino E3 Ubiquitin Protein Ligase 1; RING-Type E3 Ubiquitin Transferase Pellino Homolog 1; Pellino-Related Intracellular-Signaling Molecule; Pellino-1; E3 Ubiquitin-Protein Ligase Pellino Homolog 1; Pellino (Drosophila) Homolog 1;
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297).
Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609).
Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609).
Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).
Biological Process
Negative regulation of necroptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of NF-kappaB transcription factor activityIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Positive regulation of B cell proliferationIEA:Ensembl
Positive regulation of cytokine productionIEA:Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signalingTAS:Reactome
Positive regulation of protein ubiquitinationIEA:Ensembl
Positive regulation of toll-like receptor 3 signaling pathwayIEA:Ensembl
Positive regulation of toll-like receptor 4 signaling pathwayIEA:Ensembl
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Protein K48-linked ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Protein K63-linked ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of necroptotic processTAS:Reactome
Regulation of Toll signaling pathwayIEA:InterPro
Response to dsRNAIEA:Ensembl
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
cytosol
nucleus
PTM
Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity.
Sumoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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