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PGAM2

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.

Full Name

Phosphoglycerate Mutase 2

Function

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

Biological Process

GluconeogenesisIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Notch signaling pathwayIEA:Ensembl
Response to mercury ionIEA:Ensembl
SpermatogenesisIEA:Ensembl
Striated muscle contractionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

cytosol
extracellular exosome
nucleus

Involvement in disease

Glycogen storage disease 10 (GSD10):
A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps, exercise intolerance.

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Anti-PGAM2 antibodies

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Mouse Anti-PGAM2 Recombinant Antibody (4E9) (CBMAB-P1549-YC)

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Target: PGAM2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 4E9

Application*: WB, F, IH, IC, IF, P

Mouse Anti-PGAM2 Recombinant Antibody (3B11) (CBMAB-P1548-YC)

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Target: PGAM2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3B11

Application*: IF, WB

Mouse Anti-PGAM2 Recombinant Antibody (2F5) (CBMAB-P1547-YC)

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Target: PGAM2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey, Mouse

Clone: 2F5

Application*: IF, WB

Mouse Anti-PGAM2 Recombinant Antibody (1C11) (CBMAB-P1546-YC)

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Target: PGAM2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1C11

Application*: IF, P, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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