PGAM2

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
Full Name
Phosphoglycerate Mutase 2
Function
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Biological Process
GluconeogenesisIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Notch signaling pathwayIEA:Ensembl
Response to mercury ionIEA:Ensembl
SpermatogenesisIEA:Ensembl
Striated muscle contractionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
cytosol
extracellular exosome
nucleus
Involvement in disease
Glycogen storage disease 10 (GSD10):
A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps, exercise intolerance.
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Anti-PGAM2 antibodies

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Mouse Anti-PGAM2 Recombinant Antibody (4E9) (CBMAB-P1549-YC)

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Target: PGAM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 4E9
Application*: WB, F, IH, IC, IF, P
Datasheet SDS

Mouse Anti-PGAM2 Recombinant Antibody (3B11) (CBMAB-P1548-YC)

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Target: PGAM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B11
Application*: IF, WB
Datasheet SDS

Mouse Anti-PGAM2 Recombinant Antibody (2F5) (CBMAB-P1547-YC)

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Target: PGAM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: 2F5
Application*: IF, WB
Datasheet SDS

Mouse Anti-PGAM2 Recombinant Antibody (1C11) (CBMAB-P1546-YC)

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Target: PGAM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1C11
Application*: IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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