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Mouse Anti-PGAM2 Recombinant Antibody (4E9) (CBMAB-P1549-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphoglycerate Mutase 2. The antibody can be used for immunoassay techniques, such as WB, FC, IHC, ICC, IF, IHC-P.
See all PGAM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4E9
Antibody Isotype
IgG2a
Application
WB, FC, IHC, ICC, IF, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human PGAM2(NP_000028) produced in HEK293 cell
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoglycerate Mutase 2
Introduction
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
Entrez Gene ID
Human5224
Mouse56012
UniProt ID
HumanP15259
MouseO70250
Alternative Names
Phosphoglycerate Mutase 2; Muscle-Specific Phosphoglycerate Mutase; Phosphoglycerate Mutase 2 (Muscle); Phosphoglycerate Mutase Isozyme M; BPG-Dependent PGAM 2; PGAM-M;
Function
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Biological Process
GluconeogenesisIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Notch signaling pathwayIEA:Ensembl
Response to mercury ionIEA:Ensembl
SpermatogenesisIEA:Ensembl
Striated muscle contractionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
cytosol
extracellular exosome
nucleus
Involvement in disease
Glycogen storage disease 10 (GSD10):
A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps, exercise intolerance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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