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Mouse Anti-PGAM2 Recombinant Antibody (1C11) (CBMAB-P1546-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphoglycerate Mutase 2. The antibody can be used for immunoassay techniques, such as IF, IHC-P, WB.
See all PGAM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C11
Antibody Isotype
IgG2b
Application
IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoglycerate Mutase 2
Introduction
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
Entrez Gene ID
5224
UniProt ID
P15259
Alternative Names
Phosphoglycerate Mutase 2; Muscle-Specific Phosphoglycerate Mutase; Phosphoglycerate Mutase 2 (Muscle); Phosphoglycerate Mutase Isozyme M; BPG-Dependent PGAM 2; PGAM-M;
Function
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Biological Process
GluconeogenesisIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Notch signaling pathwayIEA:Ensembl
Response to mercury ionIEA:Ensembl
SpermatogenesisIEA:Ensembl
Striated muscle contractionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
cytosol
extracellular exosome
nucleus
Involvement in disease
Glycogen storage disease 10 (GSD10):
A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps, exercise intolerance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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