Mouse Anti-PGAM2 Recombinant Antibody (1C11) (CBMAB-P1546-YC)

Name: Mouse Anti-PGAM2 Recombinant Antibody (1C11)
SKU: CBMAB-P1546-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1C11

Application

IF, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phosphoglycerate Mutase 2

Introduction

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.

Entrez Gene ID

5224

UniProt ID

P15259

Alternative Names

Phosphoglycerate Mutase 2; Muscle-Specific Phosphoglycerate Mutase; Phosphoglycerate Mutase 2 (Muscle); Phosphoglycerate Mutase Isozyme M; BPG-Dependent PGAM 2; PGAM-M;

Function

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

Biological Process

GluconeogenesisIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Notch signaling pathwayIEA:Ensembl
Response to mercury ionIEA:Ensembl
SpermatogenesisIEA:Ensembl
Striated muscle contractionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

cytosol
extracellular exosome
nucleus

Involvement in disease

Glycogen storage disease 10 (GSD10):
A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps, exercise intolerance.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-PGAM2 Recombinant Antibody (2F5) (CAT#: CBMAB-P1547-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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