PHB2

PHB2 has ubiquitous expression in ovary (RPKM 111.2), duodenum (RPKM 62.9) and 25 other tissues.

Prohibitin 2

Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.
In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity).
Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:20959514, PubMed:11302691).
Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514, PubMed:11302691).
Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329).
Involved in mitochondrial-mediated antiviral innate immunity, activates DDX58/RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117).
In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity).
In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225).
Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
(Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection.

Activation of phospholipase C activityISS:UniProtKB
Activation of protein kinase C activityISS:UniProtKB
Antiviral innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
B cell activationISS:UniProtKB
CD40 signaling pathwayISS:UniProtKB
Cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to hypoxiaIEA:Ensembl
Cellular response to retinoic acidIEA:Ensembl
Mammary gland alveolus developmentIEA:Ensembl
Mammary gland branching involved in thelarcheIEA:Ensembl
Mitochondrion organizationManual Assertion Based On ExperimentIMP:UniProtKB
MitophagyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of intracellular estrogen receptor signaling pathwayIEA:Ensembl
Negative regulation of mammary gland epithelial cell proliferationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell cycle G1/S phase transitionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of exit from mitosisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of immunoglobulin productionISS:UniProtKB
Positive regulation of NIK/NF-kappaB signalingISS:UniProtKB
Protein import into nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of branching involved in mammary gland duct morphogenesisIEA:Ensembl
Regulation of cardiolipin metabolic processISS:UniProtKB
Regulation of cytochrome-c oxidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Response to woundingIEA:Ensembl
RIG-I signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Sister chromatid cohesionManual Assertion Based On ExperimentIDA:UniProtKB

Mitochondrion inner membrane
Cytoplasm
Nucleus
Cell membrane
Isoform 1
Mitochondrion inner membrane
Isoform 2
Mitochondrion inner membrane

Phosphorylated. Tyrosine phosphorylation is indirectly stimulated by IGFBP6.