Phospho-MPZL1 (Tyr263)

MPZL1 (Myelin Protein Zero Like 1) is a Protein Coding gene. Diseases associated with MPZL1 include Noonan Syndrome 1. Among its related pathways are Tyrosine Kinases / Adaptors and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is MPZ.

Full Name

Myelin Protein Zero Like 1

Function

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Biological Process

Cell-cell signaling Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Cellular Location

Membrane

Involvement in disease

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).
N-glycosylated. N-glycosylation is required for concanavalin A binding (PubMed:30392906).

Topology

Extracellular: 36-162
Helical: 163-183
Cytoplasmic: 184-269