PHOSPHO1

PHOSPHO1 has biased expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 3 other tissues.

Phosphoethanolamine/Phosphocholine Phosphatase

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005).
Involved in the generation of inorganic phosphate for bone mineralization (By similarity).
Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity).

Bone mineralizationISS:UniProtKB
Bone mineralization involved in bone maturationManual Assertion Based On ExperimentIBA:GO_Central
Endochondral ossificationIEA:Ensembl
Regulation of bone mineralizationIEA:UniProtKB-KW

Extracellular vesicle
Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells.