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PHOSPHO1

PHOSPHO1 has biased expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 3 other tissues.

Full Name

Phosphoethanolamine/Phosphocholine Phosphatase

Function

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005).
Involved in the generation of inorganic phosphate for bone mineralization (By similarity).
Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity).

Biological Process

Bone mineralizationISS:UniProtKB
Bone mineralization involved in bone maturationManual Assertion Based On ExperimentIBA:GO_Central
Endochondral ossificationIEA:Ensembl
Regulation of bone mineralizationIEA:UniProtKB-KW

Cellular Location

Extracellular vesicle
Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells.

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Anti-PHOSPHO1 antibodies

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Human Anti-PHOSPHO1 Recombinant Antibody (CBYC-P354) (CBMAB-P1699-YC)

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Target: PHOSPHO1

Host: Human

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYC-P354

Application*: E, WB

Mouse Anti-PHOSPHO1 Recombinant Antibody (4B2) (CBMAB-P1698-YC)

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Target: PHOSPHO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4B2

Application*: E, WB

Mouse Anti-PHOSPHO1 Recombinant Antibody (1A11) (CBMAB-P1697-YC)

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Target: PHOSPHO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A11

Application*: E, WB

Human Recombinant PHOSPHO1 protein, His Tag (V2LY-0526-LY6145)

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Target: PHOSPHO1

Expressed Host: E. coli

Sequence: Amino Acid: 1-267

Tag: His Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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