PHOSPHO1
PHOSPHO1 has biased expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 3 other tissues.
Full Name
Phosphoethanolamine/Phosphocholine Phosphatase
Function
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005).
Involved in the generation of inorganic phosphate for bone mineralization (By similarity).
Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity).
Involved in the generation of inorganic phosphate for bone mineralization (By similarity).
Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity).
Biological Process
Bone mineralizationISS:UniProtKB
Bone mineralization involved in bone maturationManual Assertion Based On ExperimentIBA:GO_Central
Endochondral ossificationIEA:Ensembl
Regulation of bone mineralizationIEA:UniProtKB-KW
Bone mineralization involved in bone maturationManual Assertion Based On ExperimentIBA:GO_Central
Endochondral ossificationIEA:Ensembl
Regulation of bone mineralizationIEA:UniProtKB-KW
Cellular Location
Extracellular vesicle
Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells.
Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells.
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Anti-PHOSPHO1 antibodies
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Target: PHOSPHO1
Host: Human
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYC-P354
Application*: E, WB
Target: PHOSPHO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4B2
Application*: E, WB
Target: PHOSPHO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A11
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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