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Mouse Anti-PHOSPHO1 Recombinant Antibody (1A11) (CBMAB-P1697-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphoethanolamine/Phosphocholine Phosphatase. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PHOSPHO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A11
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PHOSPHO1 (NP_848595, 168-266 aa) partial recombinant protein with GST tag. Immunogen sequence: CARCPANMCK HKVLSDYLRE RAHDGVHFER LFYVGDGAND FCPMGLLAGG DVAFPRRGYP MHRLIQEAQK AEPSSFRASV VPWETAADVR LHLQQVLKS
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 168-266

Target

Full Name
Phosphoethanolamine/Phosphocholine Phosphatase
Introduction
PHOSPHO1 has biased expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 3 other tissues.
Entrez Gene ID
162466
UniProt ID
Q8TCT1
Alternative Names
Phosphoethanolamine/Phosphocholine Phosphatase; Phosphatase, Orphan 1; EC 3.1.3.75;
Function
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005).
Involved in the generation of inorganic phosphate for bone mineralization (By similarity).
Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity).
Biological Process
Bone mineralizationISS:UniProtKB
Bone mineralization involved in bone maturationManual Assertion Based On ExperimentIBA:GO_Central
Endochondral ossificationIEA:Ensembl
Regulation of bone mineralizationIEA:UniProtKB-KW
Cellular Location
Extracellular vesicle
Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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