PILRA

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq]
Full Name
paired immunoglobin-like type 2 receptor alpha
Function
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.
(Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.
Biological Process
Signal transductionManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Cell membrane
Isoform 3
Secreted
Isoform 4
Secreted
Topology
Extracellular: 20-197
Helical: 198-218
Cytoplasmic: 219-303
PTM
According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.
Phosphorylated on tyrosine residues.
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Anti-PILRA antibodies

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Mouse Anti-PILRA Recombinant Antibody (3C2) (CBMAB-A6693-LY)

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Target: PILRA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C2
Application*: WB, E
Datasheet SDS

Rat Anti-PILRA Recombinant Antibody (36H2) (CBMAB-P1840-YC)

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Target: PILRA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 36H2
Application*: F, IC, IF
Datasheet SDS

Rat Anti-PILRA Recombinant Antibody (11C43) (CBMAB-P1838-YC)

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Target: PILRA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11C43
Application*: F
Datasheet SDS

Mouse Recombinant PILRA protein, His Tag (V2LY-0526-LY8780)

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Target: PILRA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-197
Tag: His Tag
Datasheet SDS

Human Recombinant PILRA protein, His Tag (V2LY-0526-LY6184)

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Target: PILRA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-226
Tag: His Tag
Datasheet SDS

Human Recombinant PILRA protein, hFc Tag (V2LY-0526-LY6183)

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Target: PILRA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-226
Tag: hFc Tag
Datasheet SDS

Human Recombinant PILRA protein, Biotin Conjugated, hFc & AVI Tag (V2LY-0526-LY6182)

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Target: PILRA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-226
Tag: hFc & AVI Tag
Datasheet SDS

Human Recombinant PILRA protein (V2LY-0526-LY6181)

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Target: PILRA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-226
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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