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Rat Anti-PILRA Recombinant Antibody (11C43) (CBMAB-P1838-YC)

Provided herein is a Rat monoclonal antibody against Human Paired Immunoglobin Like Type 2 Receptor Alpha. The antibody can be used for immunoassay techniques, such as FC.
Host Species
Rat
Application
FC
Antibody Isotype
IgG2a
Specificity
Human
Cross Reactivity
Human
Clone
11C43
Format
Liquid in sodium chloride, 0.5% BSA, 0.1% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Alternative Name
Paired Immunoglobin Like Type 2 Receptor Alpha; Inhibitory Receptor PILR-Alpha; Cell Surface Receptor FDF03; Paired Immunoglobulin-Like Type 2 Receptor Alpha; Paired Immunoglobin-Like Type 2 Receptor Alpha; FDF03;
Entrez Gene ID
UniProt ID
Cat CBMAB-P1838-YC
Conjugates
Size
Price $
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