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Rat Anti-PILRA Recombinant Antibody (11C43) (CBMAB-P1838-YC)

Provided herein is a Rat monoclonal antibody against Human Paired Immunoglobin Like Type 2 Receptor Alpha. The antibody can be used for immunoassay techniques, such as FC.
See all PILRA antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
11C43
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in sodium chloride, 0.5% BSA, 0.1% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
paired immunoglobin-like type 2 receptor alpha
Introduction
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Entrez Gene ID
29992
UniProt ID
Q9UKJ1
Alternative Names
Paired Immunoglobin Like Type 2 Receptor Alpha; Inhibitory Receptor PILR-Alpha; Cell Surface Receptor FDF03; Paired Immunoglobulin-Like Type 2 Receptor Alpha; Paired Immunoglobin-Like Type 2 Receptor Alpha; FDF03;
Function
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.
(Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.
Biological Process
Signal transductionManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Cell membrane
Isoform 3
Secreted
Isoform 4
Secreted
Topology
Extracellular: 20-197
Helical: 198-218
Cytoplasmic: 219-303
PTM
According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.
Phosphorylated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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