PITPNA
This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase
Full Name
phosphatidylinositol transfer protein, alpha
Function
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:22822086, PubMed:15522822, PubMed:18636990, PubMed:14962392).
Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086).
Preference order for PC is C16:1> C16:0> C18:1> C18:0> C20:4 and for PI is C16:1> C16:0> C18:1> C18:0> C20:4> C20:3 (PubMed:22822086).
Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086).
Preference order for PC is C16:1> C16:0> C18:1> C18:0> C20:4 and for PI is C16:1> C16:0> C18:1> C18:0> C20:4> C20:3 (PubMed:22822086).
Biological Process
Lipid metabolic process1 PublicationNAS:ProtInc
Phospholipid transportManual Assertion Based On ExperimentIDA:BHF-UCL
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Phospholipid transportManual Assertion Based On ExperimentIDA:BHF-UCL
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Nucleus
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Anti-PITPNA antibodies
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Target: PITPNA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G10
Application*: E, WB
Target: PITPNA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-270
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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