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Mouse Anti-PITPNA Recombinant Antibody (4G10) (CBMAB-P1893-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G10
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PITPNA AA 171-270 partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphatidylinositol transfer protein, alpha
Introduction
PITPNA is a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.
Entrez Gene ID
5306
UniProt ID
Q00169
Alternative Names
PI-TPalpha; PITPN; VIB1A; HEL-S-36
Function
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:22822086, PubMed:15522822, PubMed:18636990, PubMed:14962392).
Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086).
Preference order for PC is C16:1> C16:0> C18:1> C18:0> C20:4 and for PI is C16:1> C16:0> C18:1> C18:0> C20:4> C20:3 (PubMed:22822086).
Biological Process
Lipid metabolic process1 PublicationNAS:ProtInc
Phospholipid transportManual Assertion Based On ExperimentIDA:BHF-UCL
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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