PLA2G12A
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM
Full Name
phospholipase A2, group XIIA
Function
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
Biological Process
Arachidonic acid secretionIEA:InterPro
Lipid catabolic processIEA:UniProtKB-KW
Phospholipid metabolic processIEA:InterPro
Lipid catabolic processIEA:UniProtKB-KW
Phospholipid metabolic processIEA:InterPro
Cellular Location
Secreted
Cytoplasm
Cytoplasm
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Anti-PLA2G12A antibodies
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Target: PLA2G12A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C7C9
Application*: WB, F, E, MC
Target: PLA2G12A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H2C11
Application*: WB, P, F
Target: PLA2G12A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D11
Application*: WB
Target: PLA2G12A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3240
Application*: WB
Target: Pla2g12a
Sensitivity: 0.014 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: PLA2G12A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2853
Application*: F
Target: PLA2G12A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3759
Application*: IH, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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