PLIN3

Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene
Full Name
mannose-6-phosphate receptor binding protein 1
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757).
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177).
Biological Process
Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Vesicle-mediated transportManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Lipid droplet
Endosome membrane
Cytoplasm
Membrane associated on endosomes (PubMed:15545278).
Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278).
PTM
Phosphorylation at Tyr-251 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
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Anti-PLIN3 antibodies

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Mouse Anti-PLIN3 Recombinant Antibody (CBYC-P444) (CBMAB-P2134-YC)

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Target: PLIN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P444
Application*: E, WB
Datasheet SDS

Mouse Anti-PLIN3 Recombinant Antibody (CBYC-P443) (CBMAB-P2133-YC)

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Target: PLIN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P443
Application*: WB, IH
Datasheet SDS

Mouse Anti-PLIN3 Recombinant Antibody (2F7) (CBMAB-P2132-YC)

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Target: PLIN3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F7
Application*: E, P, WB
Datasheet SDS

Mouse Anti-PLIN3 Recombinant Antibody (CBYJT-1564) (CBMAB-T0602-YJ)

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Target: PLIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: CBYJT-1564
Application*: IH, WB
Datasheet SDS

Mouse Anti-PLIN3 Recombinant Antibody (CBYJT-1563) (CBMAB-T0601-YJ)

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Target: PLIN3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-1563
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-PLIN3 Recombinant Antibody (CBT2378) (V2LY-0625-LY1925)

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Target: PLIN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2378
Application*: WB, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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