Mouse Anti-PLIN3 Recombinant Antibody (2F7) (CBMAB-P2132-YC)

Name: Mouse Anti-PLIN3 Recombinant Antibody (2F7)
SKU: CBMAB-P2132-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

2F7

Application

ELISA, IHC-P, WB

Immunogen

M6PRBP1 (AAH01590, 1-435 aa) full length recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

mannose-6-phosphate receptor binding protein 1

Introduction

PLIN3 (Perilipin 3) is a protein coding gene. Diseases associated with PLIN3 include Hereditary Spastic Paraplegia. Among its related pathways are Metabolism and Vesicle-mediated transport. An important paralog of the gene is PLIN2.

Entrez Gene ID

10226

UniProt ID

O60664

Alternative Names

PP17; TIP47; M6PRBP1

Function

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757).
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177).

Biological Process

Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Vesicle-mediated transportManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Lipid droplet
Endosome membrane
Cytoplasm
Membrane associated on endosomes (PubMed:15545278).
Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278).

PTM

Phosphorylation at Tyr-251 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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