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Mouse Anti-PLIN3 Recombinant Antibody (2F7) (CBMAB-P2132-YC)

Provided herein is a Mouse monoclonal antibody against Human Perilipin 3. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all PLIN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F7
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
M6PRBP1 (AAH01590, 1-435 aa) full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
mannose-6-phosphate receptor binding protein 1
Introduction
PLIN3 (Perilipin 3) is a protein coding gene. Diseases associated with PLIN3 include Hereditary Spastic Paraplegia. Among its related pathways are Metabolism and Vesicle-mediated transport. An important paralog of the gene is PLIN2.
Entrez Gene ID
10226
UniProt ID
O60664
Alternative Names
PP17; TIP47; M6PRBP1
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757).
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177).
Biological Process
Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Vesicle-mediated transportManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Lipid droplet
Endosome membrane
Cytoplasm
Membrane associated on endosomes (PubMed:15545278).
Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278).
PTM
Phosphorylation at Tyr-251 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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