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POLR2F

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. [provided by RefSeq]

Full Name

polymerase (RNA) II (DNA directed) polypeptide F

Function

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

Biological Process

Transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

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Anti-POLR2F antibodies

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Mouse Anti-POLR2F Recombinant Antibody (2G2) (CBMAB-P2356-YC)

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Target: POLR2F

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2G2

Application*: E, IF, WB

Mouse Anti-POLR2F Recombinant Antibody (2780C3a) (CBMAB-P2355-YC)

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Target: POLR2F

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2780C3a

Application*: DB

Mouse Anti-POLR2F Recombinant Antibody (8C291) (CBMAB-R0646-CN)

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Target: POLR2F

Host: Mouse

Specificity: Human

Clone: 8C291

Application*: WB

Mouse Anti-POLR2F Recombinant Antibody (1D3) (CBMAB-R0645-CN)

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Target: POLR2F

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D3

Application*: E, WB, ICC, IP

Mouse Anti-POLR2F Recombinant Antibody (607) (CBMAB-D2192-YC)

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Target: POLR2F

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: 607

Application*: WB, IP

Mouse Anti-POLR2F Recombinant Antibody (2761C6a) (CBMAB-D2191-YC)

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Target: POLR2F

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2761C6a

Application*: WB, DB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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