PPL

PPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments.

Periplakin

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.

Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
KeratinizationIEA:UniProtKB-KW
Response to mechanical stimulusManual Assertion Based On ExperimentIEP:BHF-UCL
Wound healingManual Assertion Based On ExperimentIBA:GO_Central

Cell junction, desmosome
Cytoplasm, cytoskeleton
Cell membrane
Cytoplasm