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Rabbit Anti-PPL Recombinant Antibody (CBYC-P553) (CBMAB-P2548-YC)

Provided herein is a Rabbit monoclonal antibody against Human Periplakin. The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all PPL antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYC-P553
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Periplakin
Introduction
PPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments.
Entrez Gene ID
5493
UniProt ID
O60437
Alternative Names
AW553870
Function
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
Biological Process
Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
KeratinizationIEA:UniProtKB-KW
Response to mechanical stimulusManual Assertion Based On ExperimentIEP:BHF-UCL
Wound healingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell junction, desmosome
Cytoplasm, cytoskeleton
Cell membrane
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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