PPP1CC

PPP1CC belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme.

Protein Phosphatase 1 Catalytic Subunit Gamma

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Circadian regulation of gene expressionISS:UniProtKB
Entrainment of circadian clock by photoperiodISS:UniProtKB
Glycogen metabolic processIEA:UniProtKB-KW
MAPK cascadeTAS:Reactome
Neuron differentiationIEA:Ensembl
Positive regulation of glial cell proliferationIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIMP:MGI
Regulation of circadian rhythmManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of nucleocytoplasmic transportIEA:Ensembl

Cytoplasm
Nucleus
Nucleus, nucleolus
Nucleus, nucleoplasm
Nucleus speckle
Chromosome, centromere, kinetochore
Cleavage furrow
Midbody
Mitochondrion
Cytoplasm, cytoskeleton, microtubule organizing center
Colocalizes with SPZ1 in the nucleus (By similarity).
Colocalizes with URI1 at mitochondrion (PubMed:17936702).
Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654).
Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019).
In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654).
Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430).
Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430).
Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430).
Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430).
Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093).

Phosphorylated by NEK2.