PRSS8

PRSS8 (Serine Protease 8) is a protein coding gene. Diseases associated with PRSS8 include Ichthyosis, Follicular and Diarrhea 5, With Tufting Enteropathy, Congenital. Among its related pathways are Keratinization and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Gene Ontology annotations related to this gene includeserine-type endopeptidase activity and serine-type peptidase activity.

Serine Protease 8

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).

Positive regulation of sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisIEA:UniProtKB-KW

Prostasin
Cell membrane
Prostasin light chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Prostasin heavy chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.

Helical: 320-340