PRSS8
PRSS8 (Serine Protease 8) is a protein coding gene. Diseases associated with PRSS8 include Ichthyosis, Follicular and Diarrhea 5, With Tufting Enteropathy, Congenital. Among its related pathways are Keratinization and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Gene Ontology annotations related to this gene includeserine-type endopeptidase activity and serine-type peptidase activity.
Full Name
Serine Protease 8
Function
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Biological Process
Positive regulation of sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisIEA:UniProtKB-KW
ProteolysisIEA:UniProtKB-KW
Cellular Location
Prostasin
Cell membrane
Prostasin light chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Prostasin heavy chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Cell membrane
Prostasin light chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Prostasin heavy chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Topology
Helical: 320-340
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Anti-PRSS8 antibodies
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Target: PRSS8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C-10
Application*: WB, IP, IF, E
Target: PRSS8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P675
Application*: P, IP, WB
Target: PRSS8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2/Prostasin
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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