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PRSS8

PRSS8 (Serine Protease 8) is a protein coding gene. Diseases associated with PRSS8 include Ichthyosis, Follicular and Diarrhea 5, With Tufting Enteropathy, Congenital. Among its related pathways are Keratinization and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Gene Ontology annotations related to this gene includeserine-type endopeptidase activity and serine-type peptidase activity.

Full Name

Serine Protease 8

Function

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).

Biological Process

Positive regulation of sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisIEA:UniProtKB-KW

Cellular Location

Prostasin
Cell membrane
Prostasin light chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Prostasin heavy chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.

Topology

Helical: 320-340

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Anti-PRSS8 antibodies

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Mouse Anti-PRSS8 Recombinant Antibody (C-10) (CBMAB-P3079-YC)

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Target: PRSS8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: C-10

Application*: WB, IP, IF, E

Mouse Anti-PRSS8 Recombinant Antibody (CBYC-P675) (CBMAB-P3078-YC)

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Target: PRSS8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYC-P675

Application*: P, IP, WB

Mouse Anti-PRSS8 Recombinant Antibody (2/Prostasin) (CBMAB-P3077-YC)

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Target: PRSS8

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2/Prostasin

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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