PRSS8

PRSS8 (Serine Protease 8) is a protein coding gene. Diseases associated with PRSS8 include Ichthyosis, Follicular and Diarrhea 5, With Tufting Enteropathy, Congenital. Among its related pathways are Keratinization and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Gene Ontology annotations related to this gene includeserine-type endopeptidase activity and serine-type peptidase activity.
Full Name
Serine Protease 8
Function
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Biological Process
Positive regulation of sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisIEA:UniProtKB-KW
Cellular Location
Prostasin
Cell membrane
Prostasin light chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Prostasin heavy chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Topology
Helical: 320-340
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Anti-PRSS8 antibodies

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Mouse Anti-PRSS8 Recombinant Antibody (C-10) (CBMAB-P3079-YC)

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Target: PRSS8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C-10
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-PRSS8 Recombinant Antibody (CBYC-P675) (CBMAB-P3078-YC)

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Target: PRSS8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P675
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-PRSS8 Recombinant Antibody (2/Prostasin) (CBMAB-P3077-YC)

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Target: PRSS8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2/Prostasin
Application*: WB
Datasheet SDS

Rat Recombinant PRSS8 protein, His Tag (V2LY-0526-LY9562)

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Target: PRSS8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-322
Tag: His Tag
Datasheet SDS

Human Recombinant PRSS8 protein, His Tag-1 (V2LY-0526-LY6341)

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Target: PRSS8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 30-322
Tag: His Tag
Datasheet SDS

Human Recombinant PRSS8 protein, His Tag (V2LY-0526-LY6340)

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Target: PRSS8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 30-322
Tag: His Tag
In Vivo Assay
Datasheet SDS

Mouse Recombinant PRSS8 protein, His Tag (V2LY-0526-LY8803)

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Target: PRSS8
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 30-289
Tag: His Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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