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Mouse Anti-PRSS8 Recombinant Antibody (2/Prostasin) (CBMAB-P3077-YC)

Provided herein is a Mouse monoclonal antibody against Human Serine Protease 8. The antibody can be used for immunoassay techniques, such as WB.
See all PRSS8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2/Prostasin
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Human Prostasin, AA 108-228
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine Protease 8
Introduction
PRSS8 (Serine Protease 8) is a protein coding gene. Diseases associated with PRSS8 include Ichthyosis, Follicular and Diarrhea 5, With Tufting Enteropathy, Congenital. Among its related pathways are Keratinization and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Gene Ontology annotations related to this gene includeserine-type endopeptidase activity and serine-type peptidase activity.
Entrez Gene ID
5652
UniProt ID
Q16651
Alternative Names
CAP1; PROSTASIN
Function
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Biological Process
Positive regulation of sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisIEA:UniProtKB-KW
Cellular Location
Prostasin
Cell membrane
Prostasin light chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Prostasin heavy chain
Secreted, extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Topology
Helical: 320-340
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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