PSMA2

PSMA2 (Proteasome Subunit Alpha 2) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

Full Name

Proteasome Subunit Alpha 2

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Biological Process

Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic processISS:FlyBase
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951).
Colocalizes with TRIM5 in cytoplasmic bodies (By similarity).

PTM

Phosphorylated on tyrosine residues; which may be important for nuclear import.