Rabbit Anti-PSMA2 Recombinant Antibody (D3A4) (CBMAB-P3137-YC)

Name: Rabbit Anti-PSMA2 Recombinant Antibody (D3A4)
SKU: CBMAB-P3137-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

D3A4

Application

Specificity

Human, Mouse, Rat, Monkey, Chicken, Frog, Zebrafish, Cattle, Horse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proteasome Subunit Alpha 2

Introduction

PSMA2 (Proteasome Subunit Alpha 2) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

Entrez Gene ID

Human	5683
Mouse	19166
Rat	29669
Chicken	420772
Cattle	539141
Frog	549136
Monkey	701683
Horse	100064293

UniProt ID

Human	P25787
Mouse	P49722
Rat	P17220
Chicken	A0A1D5PHL0
Cattle	Q3T0Y5
Frog	P24495
Zebrafish	Q4VBR8
Monkey	F7AC21
Horse	F6TCI4

Alternative Names

Lmpc3

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Biological Process

Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Proteasome-mediated ubiquitin-dependent protein catabolic processISS:FlyBase
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951).
Colocalizes with TRIM5 in cytoplasmic bodies (By similarity).

PTM

Phosphorylated on tyrosine residues; which may be important for nuclear import.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PSMA2 Recombinant Antibody (3B3) (CAT#: CBMAB-P3136-YC)

Mouse Anti-PSMA2 Recombinant Antibody (MCP21) (CAT#: CBMAB-P3140-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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