PTGS1
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
Full Name
Prostaglandin-endoperoxide synthase 1
Function
Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975).
Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable).
Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable).
Biological Process
Cyclooxygenase pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Inflammatory responseIEA:InterPro
Prostaglandin biosynthetic processISS:UniProtKB
Regulation of blood pressureISS:UniProtKB
Regulation of cell population proliferationIEA:Ensembl
Response to oxidative stressIEA:InterPro
Inflammatory responseIEA:InterPro
Prostaglandin biosynthetic processISS:UniProtKB
Regulation of blood pressureISS:UniProtKB
Regulation of cell population proliferationIEA:Ensembl
Response to oxidative stressIEA:InterPro
Cellular Location
Microsome membrane
Endoplasmic reticulum membrane
Endoplasmic reticulum membrane
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Anti-PTGS1 antibodies
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CompareTarget: PTGS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AS70
Application*: WB
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Sheep
Clone: 4k2
Application*: E, WB
Target: PTGS1
Host: Mouse
Specificity: Rat
Clone: CBCNC-690
Application*: WB, ICC, P, IH-F, E
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 596002
Application*: WB
Target: PTGS1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 345305
Application*: WB, F
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Sheep, Rat
Clone: CX111
Application*: WB, E, F, IC, IF, IH
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E50
Application*: E
Target: PTGS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D2G6
Application*: WB, IP
Target: PTGS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBWJC-4332
Application*: WB, IP
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat, Sheep, Cattle, Human
Clone: CBWJC-4331
Application*: C
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Sheep, Rat
Clone: CBWJC-4330
Application*: E, F, IC, IF, IH, WB
Target: PTGS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2380
Application*: WB, IP, P, F, IC
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBYY-C2946
Application*: WB, IP, E, P, C, F, IF
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYY-C0339
Application*: WB
Target: PTGS1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 345305
Application*: WB, F
Target: PTGS1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1126
Application*: F
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYC-P756
Application*: E, IF, IH, WB
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Human, Rat, Sheep
Clone: CBYY-C2940
Application*: E, IH
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Guinea pig, Human, Rabbit, Sheep
Clone: CBYY-C2939
Application*: E, IH
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2938
Application*: E
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: 5F6/F4
Application*: WB, IP, E, P, C, F, IC/IF
Target: PTGS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Human, Rat, Sheep
Clone: 4i176
Application*: E, IH
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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