PTP69D

Protein tyrosine phosphatase 69D (Ptp69D) is a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. Ptp69D physically and genetically interacts with Dscam1 to regulate arborization of mechanosensory neurons.

Full Name

Ptp69D

Function

Possible cell adhesion receptor.

Biological Process

Axon guidanceManual Assertion Based On ExperimentIGI:FlyBase
Cell adhesionIEA:UniProtKB-KW
Defasciculation of motor neuron axonManual Assertion Based On ExperimentIMP:FlyBase
Dendrite morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Fasciculation of sensory neuron axonManual Assertion Based On ExperimentIMP:FlyBase
Motor neuron axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:FlyBase
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Synaptic target inhibitionManual Assertion Based On ExperimentIMP:FlyBase

Cellular Location

Membrane

Topology

Extracellular: 29-805
Helical: 806-823
Cytoplasmic: 824-1462