PUM2

PUM2 is a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells.

PUM2

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187).
Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276).
Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517).
Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517).
Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845).
Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866).
May regulate DCUN1D3 mRNA levels (PubMed:25349211).
May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).

Adipose tissue developmentIEA:Ensembl
Chromosome organizationIEA:Ensembl
Hair follicle developmentIEA:Ensembl
miRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrion organizationIEA:Ensembl
Positive regulation of miRNA-mediated gene silencingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of RIG-I signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Post-transcriptional regulation of gene expressionManual Assertion Based On ExperimentIDA:MGI
Regulation of chromosome segregationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of miRNA-mediated gene silencingManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of mRNA stabilityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translationIEA:UniProtKB-KW
Respiratory electron transport chainIEA:Ensembl
Skeletal system developmentIEA:Ensembl
Stress granule assemblyIEA:Ensembl

Cytoplasm
Cytoplasmic granule
Cytoplasm, perinuclear region
The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.