PYCR2

PYCR2 belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.
Full Name
Pyrroline-5-carboxylate reductase 2
Function
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP+. Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153).
Involved in cellular response to oxidative stress (PubMed:25865492).
Biological Process
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process L-proline biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proline biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Mitochondrion
Involvement in disease
Leukodystrophy, hypomyelinating, 10 (HLD10):
An autosomal recessive neurologic disorder characterized by postnatal microcephaly, severely delayed psychomotor development, hypomyelination, and reduced cerebral white-matter volume.
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Anti-PYCR2 antibodies

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Mouse Anti-PYCR2 Recombinant Antibody (3D1) (CBMAB-P3567-YC)

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Target: PYCR2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3D1
Application*: WB, F, IH, IC, IF, P
Datasheet SDS

Mouse Anti-PYCR2 Recombinant Antibody (2F11) (CBMAB-P3566-YC)

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Target: PYCR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2F11
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-PYCR2 Recombinant Antibody (2A5) (CBMAB-P3565-YC)

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Target: PYCR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 2A5
Application*: F, IC, IF, WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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