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PYCR2

PYCR2 belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.

Full Name

Pyrroline-5-carboxylate reductase 2

Function

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP+. Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153).
Involved in cellular response to oxidative stress (PubMed:25865492).

Biological Process

Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process L-proline biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proline biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Mitochondrion

Involvement in disease

Leukodystrophy, hypomyelinating, 10 (HLD10):
An autosomal recessive neurologic disorder characterized by postnatal microcephaly, severely delayed psychomotor development, hypomyelination, and reduced cerebral white-matter volume.

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Anti-PYCR2 antibodies

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Mouse Anti-PYCR2 Recombinant Antibody (3D1) (CBMAB-P3567-YC)

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Target: PYCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3D1

Application*: WB, F, IH, IC, IF, P

Mouse Anti-PYCR2 Recombinant Antibody (2F11) (CBMAB-P3566-YC)

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Target: PYCR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2F11

Application*: IC, IF, WB

Mouse Anti-PYCR2 Recombinant Antibody (2A5) (CBMAB-P3565-YC)

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Target: PYCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 2A5

Application*: F, IC, IF, WB

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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