PYCR2

PYCR2 belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.

Full Name

Pyrroline-5-carboxylate reductase 2

Function

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP+. Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153).
Involved in cellular response to oxidative stress (PubMed:25865492).

Biological Process

Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process L-proline biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proline biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Mitochondrion

Involvement in disease

Leukodystrophy, hypomyelinating, 10 (HLD10):
An autosomal recessive neurologic disorder characterized by postnatal microcephaly, severely delayed psychomotor development, hypomyelination, and reduced cerebral white-matter volume.

Anti-PYCR2 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-PYCR2 Recombinant Antibody (3D1) (CBMAB-P3567-YC)

Datasheet

SDS

Target: PYCR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3D1

Application*: WB, F, IH, IC, IF, P

Mouse Anti-PYCR2 Recombinant Antibody (2F11) (CBMAB-P3566-YC)

Datasheet

SDS

Target: PYCR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2F11

Application*: IC, IF, WB

Mouse Anti-PYCR2 Recombinant Antibody (2A5) (CBMAB-P3565-YC)

Datasheet

SDS

Target: PYCR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 2A5

Application*: F, IC, IF, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)