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Mouse Anti-PYCR2 Recombinant Antibody (2A5) (CBMAB-P3565-YC)

Provided herein is a Mouse monoclonal antibody against Human Pyrroline-5-carboxylate reductase 2. The antibody can be used for immunoassay techniques, such as FC, ICC, IF, WB.
See all PYCR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
2A5
Antibody Isotype
IgG1
Application
FC, ICC, IF, WB

Basic Information

Immunogen
Full length human recombinant protein of human PYCR2 (NP_037460) produced in HEK293T cell
Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pyrroline-5-carboxylate reductase 2
Introduction
PYCR2 belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.
Entrez Gene ID
Human29920
Monkey699808
UniProt ID
HumanQ96C36
MonkeyF7GP60
Alternative Names
P5CR2; HLD10
Function
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP+. Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153).
Involved in cellular response to oxidative stress (PubMed:25865492).
Biological Process
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process L-proline biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proline biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Mitochondrion
Involvement in disease
Leukodystrophy, hypomyelinating, 10 (HLD10):
An autosomal recessive neurologic disorder characterized by postnatal microcephaly, severely delayed psychomotor development, hypomyelination, and reduced cerebral white-matter volume.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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