RAB1A

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

Full Name

RAB1A, Member RAS Oncogene Family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626).
Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626).
RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926).
Required to modulate the compacted morphology of the Golgi (PubMed:26209634).
Regulates the level of CASR present at the cell membrane (PubMed:20861236).
Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577).
Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626).
Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).

Biological Process

Biological Process autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process growth hormone secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome transportIEA:Ensembl
Biological Process positive regulation of glycoprotein metabolic processManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process vesicle transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process virion assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Golgi apparatus
Endoplasmic reticulum
Early endosome
Cytoplasm, cytosol
Membrane
Melanosome
Alternates between membrane-associated and cytosolic forms.

PTM

Phosphorylated by CDK1 kinase during mitosis.
(Microbial infection) Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI) (PubMed:21822290).
Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB (PubMed:22158903).
(Microbial infection) Glycosylated by S.typhimurium protein Ssek3: arginine GlcNAcylation prevents GTPase activity, thereby disrupting vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment.