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Mouse Anti-RAB1A Recombinant Antibody (3F10) (CBMAB-R0728-CN)

This product is a Mouse antibody that recognizes RAB1A. The antibody 3F10 can be used for immunoassay techniques such as: ELISA, WB.
See all RAB1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F10
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 106-205, from human RAB1A, with GST tag
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites

Target

Full Name
RAB1A, Member RAS Oncogene Family
Introduction
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]
Entrez Gene ID
5861
UniProt ID
P62820
Alternative Names
RAB1A, Member RAS Oncogene Family; YPT1-Related Protein; RAB1; RAB1, Member RAS Oncogene Family; Rab GTPase YPT1 Homolog (Yeast); Ras-Related Protein Rab-1A; GTP Binding Protein Rab1a; Rab GTPase YPT1 Homolog; YPT1;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626).
Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626).
RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926).
Required to modulate the compacted morphology of the Golgi (PubMed:26209634).
Regulates the level of CASR present at the cell membrane (PubMed:20861236).
Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577).
Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626).
Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
Biological Process
Biological Process autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process growth hormone secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome transportIEA:Ensembl
Biological Process positive regulation of glycoprotein metabolic processManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process vesicle transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process virion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Golgi apparatus
Endoplasmic reticulum
Early endosome
Cytoplasm, cytosol
Membrane
Melanosome
Alternates between membrane-associated and cytosolic forms.
PTM
Phosphorylated by CDK1 kinase during mitosis.
(Microbial infection) Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI) (PubMed:21822290).
Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB (PubMed:22158903).
(Microbial infection) Glycosylated by S.typhimurium protein Ssek3: arginine GlcNAcylation prevents GTPase activity, thereby disrupting vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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