RAB32

Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM

Full Name

RAB32, member RAS oncogene family

Function

Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851).
Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211).
Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991).
In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).

Biological Process

Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosome to melanosome transportManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process melanosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process phagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to membraneManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process vesicle-mediated transportIEA:InterPro

Cellular Location

Mitochondrion
Mitochondrion outer membrane
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Melanosome
Melanosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).