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Mouse Anti-RAB32 Recombinant Antibody (1C7) (CBMAB-R0818-CN)

This product is a Mouse antibody that recognizes RAB32. The antibody 1C7 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all RAB32 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C7
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to RAB32, aa. 136-226 (NP_006825) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB32, member RAS oncogene family
Introduction
The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
Entrez Gene ID
10981
UniProt ID
Q13637
Alternative Names
RAB32, Member RAS Oncogene Family;
Function
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851).
Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211).
Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991).
In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).
Biological Process
Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosome to melanosome transportManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process melanosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process phagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to membraneManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process vesicle-mediated transportIEA:InterPro
Cellular Location
Mitochondrion
Mitochondrion outer membrane
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Melanosome
Melanosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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