RAB38

RAB38 (RAB38, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB38 include Frontotemporal Dementia and Hermansky-Pudlak Syndrome 5. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RAB32.

Full Name

RAB38, Member RAS Oncogene Family

Function

May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity).
Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211).
Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991).
In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)

Biological Process

Biological Process endosome to melanosome transportManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process melanosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process phagosome acidificationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process platelet dense granule organizationIEA:Ensembl
Biological Process positive regulation of phosphatidylcholine biosynthetic processIEA:Ensembl
Biological Process protein localization to membraneManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process protein transport1 PublicationNAS:UniProtKB
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB
Biological Process vesicle-mediated transportIEA:InterPro

Cellular Location

Cell membrane
Melanosome
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Melanosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).

PTM

Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.