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Mouse Anti-RAB38 Recombinant Antibody (7F1) (CBMAB-R0836-CN)

This product is a Mouse antibody that recognizes RAB38. The antibody 7F1 can be used for immunoassay techniques such as: ELISA, WB.
See all RAB38 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7F1
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 115-212 from RAB38 (NP_071732) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB38, Member RAS Oncogene Family
Introduction
RAB38 (RAB38, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB38 include Frontotemporal Dementia and Hermansky-Pudlak Syndrome 5. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RAB32.
Entrez Gene ID
23682
UniProt ID
P57729
Alternative Names
RAB38, Member RAS Oncogene Family; Melanoma Antigen NY-MEL-1; Rab-Related GTP-Binding Protein; Ras-Related Protein Rab-38; NY-MEL-1; RrGTPbp;
Function
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity).
Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211).
Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991).
In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)
Biological Process
Biological Process endosome to melanosome transportManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process melanosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process phagosome acidificationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process platelet dense granule organizationIEA:Ensembl
Biological Process positive regulation of phosphatidylcholine biosynthetic processIEA:Ensembl
Biological Process protein localization to membraneManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process protein transport1 PublicationNAS:UniProtKB
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB
Biological Process vesicle-mediated transportIEA:InterPro
Cellular Location
Cell membrane
Melanosome
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Melanosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
PTM
Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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